Flex Wise

Flex wise is a comprehensive, high-potency, joint-flexibility support formula delivered in a unique, extremely palatable, highly absorbable, emulsified liquid. WisdOM-3? is an emulsification process proven in human clinical trials to double omega-3 bioavailability. Both glucosamine sulfate and chondroitin sulfate, when used in the long-term, help to prevent knee joint spaces from narrowing.6,7 They also protect against the degeneration of cartilage8,9,10 while enhancing mobility and joint function.11,12 Vitamins A and D aid in the development and maintenance of bones and teeth. Vitamins C and E are also valuable antioxidants. Vitamin C supports the development and maintenance of cartilage and connective tissue formation, and aids in wound healing. Vitamin D helps in the development and maintenance of bones and teeth.

Comprehensive, high-potency, joint health support formula
Provides therapeutic doses of naturally-enriched fish oil, glucosamine and chondroitin for occasional pain relief.1,2,3,4 Delivers vitamins A and D to aid in the development of bones and teeth.

Emulsified for enhanced absorption WisdOM-3? is a proprietary emulsification process proven in human clinical trials to double omega-3 bioavailability while improving overall taste for increased patient compliance.

Great taste
Natural tropical orange and pineapple flavoured liquid maximizes patient compliance.

Scientific Rationale:

• Glucosamine sulfate (1500 mg per day) and omega-3 fatty acids from fish oil (200 mg per day), when given in combination, resulted in a typical reduction in morning stiffness and pain in hips and knees than when glucosamine sulfate was given on its own.
• Chondroitin supplementation, 800 mg per day for a period of three months, may benefit knee health by preventing joint space narrowing and helping maintain knee comfort and function.

Serving Size: 1 tablespoon(15 ml)
Servings Per Container: 20

Active Ingredients:

• Vitamin A (vitamin A palmitate/cod liver oil) 1200 mcg RAE / 4000 IU
• Vitamin D (cholecalciferol) 15 mcg / 600 IU
• Vitamin E (d-alpha tocopheryl acetate) . 30 mg AT / 45 IU
• Fish oil (anchovy and sardine) . 2370 mg
  Yielding
  Eicosapentaenoic acid (EPA) . 500 mg
  Docosahexaenoic acid (DHA) 350 mg
• Cod liver oil 900 mg
  Yielding
  Eicosapentaenoic acid (EPA) . 60 mg
  Docosahexaenoic acid (DHA) . 90 mg
• Glucosamine hydrochloride (from shrimp & crab exoskeletons) 1500 mg
• Chondroitin sulfate (chondroitin sulfate sodium from avian cartilage) . 300 mg

Inactive Ingredients: Concentrated pineapple and orange juices, fructose, purified water, modified corn starch, acacia gum, citric acid, vanilla flavour, hydroxypropyl alginate, potassium sorbate, natural mixed tocopherols, lemon oil, potassium chloride, ginger oil, caramel colour.

Recommended Dosage:
One tablespoon taken daily with a meal or as professionally directed. Use for a minimum of four weeks to see beneficial effects.

Risk information: If you are pregnant or breastfeeding, consult your healthcare practitioner prior to use. If symptoms worsen, consult your healthcare practitioner.

References:

1. Phitak T, Pothacharoen P, Kongtawelert P. Comparison of glucose derivatives effects on cartilage degradation. BMC Musculoskeletal Disorders (2010): 15:11 (Jul): 162. Pubmed. Internet. 26 Aug. 2010..
2. Pavelka K, Gatterova J, Olejarova M, Machacek S. Giacovelli G, Rovati LC. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med (2002):162 (18) (Oct 14): 2113-23..
Pubmed. Internet. 26 Aug. 2010..
3. Calder PC. Supplementation: n-3 Fatty Acids: Recommendations for Therapeutics and Prevention. N-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases. American Journal of Clinical Nutrition. (2006): Vol. 83, No. 6, S1505-1519S, June 2006.
4. Ruggiero C, Lattanzio F, Lauretani F, Gasperini B, Andres-Lacueva C, Cherubini A. Omega-3 polyunsaturated fatty acids and immunemediated diseases: inflammatory bowel disease and rheumatoid arthritis. Curr Pharm Des. 2009;15(36):4135-48. Pubmed. Internet. 26 Aug 2010..
5. NHPD. Product Monograph ? Multi Vitamin/Mineral Supplement. 2007..
6. Pavelka et al. 2002..
7. Hochberg MC. Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebocontrolled trials of 2-year duration. Osteoarthritis Cartilage. 2010 Jun;18 Suppl 1:S28-31. Epub 2010 Apr 27. Pubmed. Internet. 26 Aug. 2010..
8. Phitak et al. 2010.
9. Pavelka et al. 2002..
10. Martel-Pelletier J, Kwan Tat S, Pelletier JP. Effects of chondroitin sulfate in the pathophysiology of the osteoarthritic joint: a narrative review. Osteoarthritis Cartilage. (2010) Jun;18 Suppl 1:S7-11. Epub 2010 Apr 27. Pubmed. Internet. 26 Aug. 2010..
11. Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JY. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Intern Med (2003): 163 (13) (Jul 14):1514-22. Pubmed. Internet. 26 Aug. 2010..
12. Uebelhart D, Malaise M, Marcolongo R, de Vathaire F, Piperno M, Mailleux E, Fioravanti A, Matoso L, Vignon E. Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo. Osteoarthritis Cartilage. 2004 Apr;12(4):269-76. Pubmed. Internet. 26 Aug. 2010..
13. Calder 2010.
14. Uebelhart 269-76.