HLC Immunobiotics

Advanced Energy and Immune Support.

HLC immunobiotics is a unique combination of probiotics and nutrients that provides broad-spectrum support to the immune system as well as helps to bolster energy levels. Can be used at any time of the day, but is most effective when taken in the morning.

Enhanced immune support
Boosts immunity with zinc and echinacea. Enhances antioxidant levels with vitamin C and CoQ10.

Increased energy support
Increase energy levels with B-complex vitamins.1 Promote endurance with guaran.

High potency probiotic to optimize intestinal health
High potency probiotic to optimize intestinal health.

Scientific Rationale:

• Vitamin C and zinc support immune function.
• Vitamin D and beta-glucan demonstrate immunological activity.
• Guarana extract can temporarily promote alertness and wakefulness, enhance cognitive performance, relieve fatigue, promote endurance, and enhance motor performance.
• Echinacea, elderberry and propolis help support immune function.

Serving Size: 1 capsule
Servings Per Container: 30

Active Ingredients:

• Vitamin C (ascorbic acid) . . . . . . . . . . . 125 mg
• Vitamin D (cholecalciferol) . . . . . . . . 12.5 mcg / 500 IU
• Thiamine (thiamine mononitrate) . . . . . 4.2 mg
• Riboflavin . . . . . . . . . . 4.8 mg
• Niacinamide . . . . . . . . 18 mg
• Vitamin B6 (pyridoxine hydrochloride) . 6 mg
• Folate (folic acid) . 400 mcg
• Vitamin B12 (cyanocobalamin) . 10 mcg
• Biotin . . . . . . . . . . . . . . . . . . . . . . . . . . . . 200 mcg
• Pantothenic acid (calcium d-pantothenate) . 12 mg
• Zinc (zinc citrate) . . . . . . . . . . . . . . . . . . . . . 7.5 mg
• Selenium (sodium selenite) . . . . . . . . 100 mcg
• Coenzyme Q10 (yeast fermentation) . . . . . . . . . . . . . . . . . 30 mg
• Guaran (Paullinia cupana) seed std. extract (11% caffeine) . . 70 mg
• Yeast (Saccharomyces cerevisiae) std. extract (70% beta-1,3-glucans) . . . 60 mg
• European elder (Sambucus nigra)
fruit juice powder . . . . . . . . . . . . . . . . . . 75 mg (equivalent to 0.45 ml fruit juice / 525 mg fresh fruit)
• Echinacea (Echinacea purpurea) root std. extract (4% echinacosides) . . . . . . 40 mg
• Propolis resin (from honey bee hive) . . 30 mg
• HLC Consortium . 12.5 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34)

Inactive Ingredients: Hypromellose, microcrystalline cellulose, silica, vegetable magnesium stearate.

Recommended Dosage:
One capsule taken two times daily with meals, a few hours before or after taking other medications, or as professionally directed.

Risk information: If you are experiencing nausea, fever, vomiting, bloody diarrhoea or severe abdominal pain; if you have an immune-compromised condition; or if you are allergic to plants of the Asteraceae/Compositae/Daisy family, do not use. If you are pregnant or breastfeeding or if you are allergic to bee products, poplar tree products or balsam of Peru, consult your healthcare practitioner prior to use. If you have a progressive systemic disease such as tuberculosis, leukosis, collagenosis or multiple sclerosis; if you have high blood pressure, glaucoma and/or detrusor instability; or if you have a history of non-melanoma skin cancer, consult your healthcare practitioner prior to use. If you are taking lithium, immunosuppressants or blood pressure medication, consult your healthcare practitioner prior to use. Consumption with other caffeinecontaining products or with natural health products or drugs which increase blood pressure is not recommended. If symptoms of digestive upset occur, worsen or persist beyond three days, discontinue use and consult your healthcare practitioner. Hypersensitivity/allergy is known to occur; in which case, discontinue use.

Seroyal research-driven probiotic therapies:

• Clinically proven in randomized, double-blind, placebo-controlled human trials at 25 billion CFU**
  - Reduces symptoms of Irritable Bowel Syndrome (IBS)14
  - Prevents intestinal microflora disruption post-antibiotics15, 16
  - Reduces the incidence of C. difficile associated diarrhea17
• Proprietary non-pathogenic human-sourced microflora bacterial strains
  - Strong epithelial adherence
  - Naturally high tolerance to stomach acid
• Ambient-Safe
  - Manufacturing allows for ambient temperature (20-25C) storage and 2 year shelf-life without compromising product stability and still meet or exceed label claims.

References:

1. A Natural Health Products Directorate. Product Monograph Multi-Vitamin/Mineral Supplement [internet] October 22, 2007 [Accessed Sept 17 2010]. Available at: http://www.hc-sc.gc.ca/ dhp-mps/prodnatur/applications/licen-prod/monograph/multi_vitmin_suppl-eng.php.
2. Natural Health Products Directorate (NHPD). Product Monograph Caffeinated Energy Drinks. [internet] December 30, 2007 [Accessed Sept. 16, 2010]. Available at: http://www.hc-sc.gc.ca/ dhp-mps/alt_formats/hpfb-dgpsa/pdf/prodnatur/mono_caffe-cafe-eng.pd.
3. Natural Medicines Comprehensive Database. Echinacea Monograph [internet] Accessed: 17 Sept 2010. Available at: http://naturaldatabase.therapeuticresearch.com.ezproxy.ccnm.edu/nd/Search.as px?cs=&s=ND&pt=100&id=981&ds=&name=ECHINACEA&searchid=22786210.
4. Natural Medicines Comprehensive Database. Vitamin C Monograph. [internet] Accessed: 17 Sept 2010. Available at: http://naturaldatabase.therapeuticresearch.com.ezproxy.ccnm.edu/nd/Search.as px?cs=&s=ND&pt=100&id=1001&ds=&name=Vitamin+C+(VITAMIN+C+(ASCORBIC+ACID ))&searchid=22786210.
5. Natural Medicines Comprehensive Database. Zinc Monograph. [internet] Accessed 17 Sept 2010. Available at: http://naturaldatabase.therapeuticresearch.com.ezproxy.ccnm.edu/nd/Search.aspx?cs =&s=ND&pt=100&id=982&ds=&name=ZINC&searchid=22786210.
6. Natural Medicines Comprehensive Database. Vitamin D Monograph. [internet] Accessed: 17 Sept 2010. Available at: http://naturaldatabase.therapeuticresearch.com.ezproxy.ccnm.edu/nd/Search.as px?cs=&s=ND&pt=100&id=929&ds=&name=VITAMIN+D&searchid=22786210. Lehne G, Haneberg B, Gaustad P, Johansen PW, Preus H, Abrahamsen TG. Oral administration of a new soluble branched beta-1,3-D-glucan is well tolerated and can lead to increased salivary concentrations of immunoglobulin A in healthy volunteers. Clin Exp Immunol. 2006 Jan;143(1):65-9.
7. NHPD. Product Monograph Caffeinated Energy Drinks.
8. NMCD. Echinacea Monograph.
9. Vlachojannis JE, Cameron M, Chrubasik S. A sytematic review on the sambuci fructus effect and efficacy profiles. Phytother Res. 2010 Jan;24(1):1-8. Pubmed 17 Sept. 2010.
10. NMCD. Echinacea Monograph.
11. Lofty M. Biological Activity of Bee Propolis in Health and Disease. Asian Pac J Cancer Prev. 2006;7:22-31.
12. Lofty 2006
13. Williams EA, et al. Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. 2009; 29(1): 97-103.
14. Plummer SF, et al. Effects of probiotics on the composition of the intestinal microbiota following antibiotic therapy. Int J Antimicrob Agents. 2005; 26(1); 69-74.
15. Madden JA, et al. Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: a double-blind, placebo-controlled pilot study. Int Immunopharmacol. 2005; (6): 1091-7.
16. Plummer S, et al. Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea. Int Microbiol. 2004;7(1):59-62.